Medical management of claudication

J Vasc Surg. 2017 Jul;66(1):275-280. doi: 10.1016/j.jvs.2017.02.040. Epub 2017 May 19.


Peripheral artery disease (PAD) is common and associated with significant morbidity and mortality. Optimal medical management of PAD is required for each patient, irrespective of the decision regarding lower extremity revascularization. The goals include reducing cardiovascular morbidity and mortality and improving quality of life. The approach should consist of aggressive and individualized risk factor modification including smoking cessation, antiplatelet therapy, a statin, and an angiotensin-converting enzyme inhibitor. Exercise is critical for cardiovascular health and highly effective for improving claudication symptoms. Cilostazol may be considered for symptomatic treatment in certain patients.

Publication types

  • Review

MeSH terms

  • Cardiovascular Agents / therapeutic use*
  • Comorbidity
  • Drug Therapy, Combination
  • Humans
  • Intermittent Claudication / diagnosis
  • Intermittent Claudication / drug therapy*
  • Intermittent Claudication / mortality
  • Intermittent Claudication / physiopathology
  • Life Style
  • Lower Extremity / blood supply*
  • Peripheral Arterial Disease / diagnosis
  • Peripheral Arterial Disease / drug therapy*
  • Peripheral Arterial Disease / mortality
  • Peripheral Arterial Disease / physiopathology
  • Quality of Life
  • Risk Factors
  • Risk Reduction Behavior
  • Treatment Outcome


  • Cardiovascular Agents