Clonal Dissemination of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae in Neonates

Antimicrob Agents Chemother. 2017 Jul 25;61(8):e00385-17. doi: 10.1128/AAC.00385-17. Print 2017 Aug.

Abstract

Five OXA-232 carbapenemase-producing Klebsiella pneumoniae isolates, belonging to the pandemic clone sequence type 15 (ST15), were isolated from neonates and coproduced blaCTX-M-15 and blaSHV-1 genes. All isolates were resistant to ertapenem (MICs of >32 μg/ml) and meropenem (MICs of 4 to 8 μg/ml) and susceptible or intermediate to imipenem (MICs of 1 to 2 μg/ml). The blaOXA-232 gene was located on a ColE-type transformable plasmid of 6,141 bp. To the best of our knowledge, this is the first report of OXA-232 carbapenemase among clinical isolates in China.

Keywords: Klebsiella pneumoniae; OXA-232; ST15; clonal dissemination; neonates.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics*
  • Bacterial Proteins / metabolism
  • China
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Ertapenem
  • Humans
  • Imipenem / pharmacology
  • Klebsiella Infections / drug therapy
  • Klebsiella Infections / microbiology
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / enzymology
  • Klebsiella pneumoniae / genetics*
  • Klebsiella pneumoniae / isolation & purification
  • Meropenem
  • Microbial Sensitivity Tests
  • Plasmids / genetics
  • Thienamycins / pharmacology
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism
  • beta-Lactams / pharmacology

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Thienamycins
  • beta-Lactams
  • Imipenem
  • beta-lactamase CTX-M-15
  • beta-lactamase PIT-2
  • beta-Lactamases
  • beta-lactamase OXA-232, Klebsiella pneumoniae
  • carbapenemase
  • Meropenem
  • Ertapenem