The efficacy of orbital ultrasonography and magnetic resonance imaging findings with direct measurement of intracranial pressure in distinguishing papilledema from pseudopapilledema

Childs Nerv Syst. 2017 Sep;33(9):1501-1507. doi: 10.1007/s00381-017-3454-6. Epub 2017 May 22.

Abstract

Introduction: The goal of this study was to evaluate the utility of orbital ultrasonography and magnetic resonance imaging in the diagnosis of idiopathic intracranial hypertension (IIH).

Method: We reviewed the medical records of patients referred to our department for suspected IIH.

Results: Seven children were diagnosed with IIH. Nine children revealed pseudopapilledema by optic coherence tomography and/or orbital ultrasonography. When the axial sequences were reexamined, patients with papilledema had optic nerve sheath (ONS) enlargement (6.62 ± 0.70 mm); patients with pseudopapilledema had ONS diameter as 4.62 ± 0.64 mm. There was a significant correlation between the CSF opening pressure and ONS diameter (p < 0.005, r = 0.661). In the papilledema group, the presence of proposed subtle markers as increased tortuosity in the optic nerve was found in six patients. Five of seven patients had a target sign, intraocular protrusion of the optic nerve, and posterior globe flattening.

Discussion: Ophthalmological review is important to avoid unnecessary procedures for detection of true papilledema. ONS diameter is a reliable neuroimaging marker as other subtle markers.

Keywords: Drusen; Idiopathic intracranial hypertension; Orbital ultrasonography; Papilledema; Pseudopapilledema.

Publication types

  • Observational Study

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Eye Diseases, Hereditary / complications
  • Eye Diseases, Hereditary / diagnostic imaging*
  • Female
  • Humans
  • Intracranial Hypertension / diagnostic imaging*
  • Intracranial Hypertension / etiology
  • Intracranial Pressure
  • Magnetic Resonance Imaging
  • Male
  • Optic Nerve / diagnostic imaging
  • Optic Nerve Diseases / complications
  • Optic Nerve Diseases / diagnostic imaging*
  • Papilledema / complications
  • Papilledema / diagnostic imaging*
  • Retrospective Studies
  • Ultrasonography

Supplementary concepts

  • Pseudopapilledema