Lobophorin K, a New Natural Product With Cytotoxic Activity Produced by Streptomyces Sp. M-207 Associated With the Deep-Sea Coral Lophelia Pertusa

Mar Drugs. 2017 May 19;15(5):144. doi: 10.3390/md15050144.

Abstract

The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedition to the submarine Avilés Canyon. Its structure was determined using a combination of spectroscopic techniques, mainly ESI-TOF MS and 1D and 2D NMR. This new natural product displayed cytotoxic activity against two human tumor cell lines, such as pancreatic carcinoma (MiaPaca-2) and breast adenocarcinoma (MCF-7). Lobophorin K also displayed moderate and selective antibiotic activity against pathogenic Gram-positive bacteria such as Staphylococcus aureus.

Keywords: Cantabrian Sea-derived actinobacteria; Streptomyces; antitumor; lobophorins; spirotetronate antibiotic.

MeSH terms

  • Animals
  • Anthozoa / microbiology*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Humans
  • Macrolides / chemistry*
  • Macrolides / metabolism
  • Macrolides / pharmacology*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Phylogeny
  • Streptomyces / genetics
  • Streptomyces / metabolism*

Substances

  • Antineoplastic Agents
  • Macrolides
  • lobophorin K