Cloning and functional characterization of a retinoid X receptor orthologue in Platynereis dumerilii: An evolutionary and toxicological perspective

Chemosphere. 2017 Sep;182:753-761. doi: 10.1016/j.chemosphere.2017.05.064. Epub 2017 May 20.


In the present work we provide the first isolation and functional characterization of a RXR orthologue in an annelid species, the Platynereis dumerilii. Using an in vitro luciferase reporter assay we evaluated the annelid receptor ability to respond to ligand 9-cis-retinoic acid, TBT and TPT. Our results show that the annelid RXR responds to 9-cis-retinoic acid and to the organotins by activating reporter gene transcription. The findings suggest a conserved mode of action of the receptor in response to a common signaling molecule and modulation by organotin compounds between vertebrates and Lophotrochozoans.

Keywords: Annelid; Endocrine disruption; Evolution; Retinoid X receptor; Tributyltin; Triphenyltin.

MeSH terms

  • Alitretinoin
  • Animals
  • Biological Evolution
  • Gene Expression Regulation / physiology
  • Ligands
  • Organotin Compounds
  • Polychaeta / metabolism*
  • Retinoid X Receptors / genetics
  • Retinoid X Receptors / metabolism*
  • Transcriptional Activation / drug effects
  • Tretinoin / metabolism


  • Ligands
  • Organotin Compounds
  • Retinoid X Receptors
  • Alitretinoin
  • Tretinoin