Resistant Starch Regulates Gut Microbiota: Structure, Biochemistry and Cell Signalling

Cell Physiol Biochem. 2017;42(1):306-318. doi: 10.1159/000477386. Epub 2017 May 25.


Starch is one of the most popular nutritional sources for both human and animals. Due to the variation of its nutritional traits and biochemical specificities, starch has been classified into rapidly digestible, slowly digestible and resistant starch. Resistant starch has its own unique chemical structure, and various forms of resistant starch are commercially available. It has been found being a multiple-functional regulator for treating metabolic dysfunction. Different functions of resistant starch such as modulation of the gut microbiota, gut peptides, circulating growth factors, circulating inflammatory mediators have been characterized by animal studies and clinical trials. In this mini-review, recent remarkable progress in resistant starch on gut microbiota, particularly the effect of structure, biochemistry and cell signaling on nutrition has been summarized, with highlights on its regulatory effect on gut microbiota.

Keywords: Gut microbiota; Nutrition; Resistant starch.

Publication types

  • Review

MeSH terms

  • Animals
  • Glucagon-Like Peptide-1 Receptor / metabolism
  • Humans
  • Interleukin-10 / metabolism
  • Intestines / microbiology*
  • Microbiota / drug effects*
  • Signal Transduction / drug effects
  • Starch / chemistry
  • Starch / metabolism
  • Starch / pharmacology*


  • Glucagon-Like Peptide-1 Receptor
  • Interleukin-10
  • Starch