First report of the qnrA determinant in Shigella sonnei isolated from China

H M Qian; T T Qin; G Y Liu; J Li; P Ma; X X Kong; B Gu; C J Bao

doi:10.1017/S0950268817000917

First report of the qnrA determinant in Shigella sonnei isolated from China

Epidemiol Infect. 2017 Aug;145(11):2193-2196. doi: 10.1017/S0950268817000917. Epub 2017 May 24.

Authors

H M Qian¹, T T Qin², G Y Liu², J Li², P Ma², X X Kong¹, B Gu², C J Bao¹

Affiliations

¹ Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China.
² Medical Technology School, Xuzhou Medical University,Xuzhou 221004,China.

Abstract

We investigated the first presence of qnrA among Shigella sonnei clinical isolates in Jiangsu Province, China. The qnrA-positive isolates coexisted with the mutation in gyrA at codon 83, these isolates were resistant to nalidixic acid and 22·2% (2 of 9) of them were resistant to norfloxacin.

Keywords: Shigella sonnei; qnrA; China; fluoroquinolones.

MeSH terms

Anti-Bacterial Agents / pharmacology*
Bacterial Proteins / genetics*
China
Drug Resistance, Bacterial / genetics*
Nalidixic Acid / pharmacology*
Norfloxacin / pharmacology*
Shigella sonnei / drug effects*
Shigella sonnei / genetics
Shigella sonnei / isolation & purification

Substances

Anti-Bacterial Agents
Bacterial Proteins
Nalidixic Acid
Norfloxacin