Vascular heterogeneity and specialization in development and disease

Nat Rev Mol Cell Biol. 2017 Aug;18(8):477-494. doi: 10.1038/nrm.2017.36. Epub 2017 May 24.


Blood and lymphatic vessels pervade almost all body tissues and have numerous essential roles in physiology and disease. The inner lining of these networks is formed by a single layer of endothelial cells, which is specialized according to the needs of the tissue that it supplies. Whereas the general mechanisms of blood and lymphatic vessel development are being defined with increasing molecular precision, studies of the processes of endothelial specialization remain mostly descriptive. Recent insights from genetic animal models illuminate how endothelial cells interact with each other and with their tissue environment, providing paradigms for vessel type- and organ-specific endothelial differentiation. Delineating these governing principles will be crucial for understanding how tissues develop and maintain, and how their function becomes abnormal in disease.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Vessels / cytology
  • Cell Differentiation / physiology
  • Endothelial Cells / cytology*
  • Endothelial Cells / metabolism
  • Endothelial Cells / physiology
  • Humans
  • Lymphatic Vessels / cytology