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. 2017 Jul 18;8(29):47497-47506.
doi: 10.18632/oncotarget.17668.

Resveratrol May Reverse the Effects of Long-Term Occupational Exposure to Electromagnetic Fields on Workers of a Power Plant

Free PMC article

Resveratrol May Reverse the Effects of Long-Term Occupational Exposure to Electromagnetic Fields on Workers of a Power Plant

Dan Zhang et al. Oncotarget. .
Free PMC article


High-voltage electricity lines are known to generate extremely low-frequency electromagnetic fields (ELF-EMFs). With the process of urbanization, increasing concerns has been focused on the potentially hazardous impacts of ELF-EMF on human health, and the conclusions are controversial. Little is known about the method of prevention against ELF-EMF induced healthy problems. A total of 186 male workers with occupational exposure to high-voltage electricity lines, and 154 male subjects with insignificant exposure as reference control were enrolled in this study. Resveratrol or placebo was given as dietary supplements (500 mg twice daily), and several inflammatory biomarkers and biomarkers of oxidative stress were assessed. Workers who had long-term exposure to high-voltage electricity lines exhibited elevated urinary levels of 8-hydroxy-2-deoxy-guanosine (8-OHdG) and F2-isoprostane, compared to the reference group. Lower plasma nuclear factor kappa B (NF-κB) and interleukin (IL)-6 were observed in exposed workers compared to the reference group. Resveratrol significantly reversed the adverse impacts of ELF-EMF. Stimulated cytokine production by resveratrol was found in exposed workers but not in the reference group. This study supported that occupational and long-term exposure to high-voltage electricity lines has an adverse effect on homeostasis of human body, and resveratrol supplement could be an effective protection strategy against the adverse effects induced by ELF-EMFs.

Keywords: ELF-EMFs; biomarkers of oxidative stress; high-voltage electricity lines; inflammatory; resveratrol.

Conflict of interest statement


The authors declare that they have no conflicts of interest.


Figure 1
Figure 1. Flow diagram of subjects screening
A total of 2456 subjects were enrolled in the current study. Workers exposed under 110–420 kV and the reference participants were treated with placebo or resveratrol.

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