Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 13 (50), 326-331

Anti-Fatigue Effect of Green Tea Polyphenols (-)-Epigallocatechin-3-Gallate (EGCG)

Yu-Song TengDi Wu

Anti-Fatigue Effect of Green Tea Polyphenols (-)-Epigallocatechin-3-Gallate (EGCG)

Yu-Song Teng et al. Pharmacogn Mag.

Abstract

Background: (-)-Epigallocatechin-3-gallate (EGCG) is the most abundant of the green tea polyphenols that exhibit a variety of bioactivities. The objective of this study was to evaluate the anti-fatigue effect of EGCG by forced swimming exercise.

Materials and methods: The mice were divided into one control group and three EGCG-treated groups. The control group was administered with distilled water and EGCG-treated groups were administered with different dose of EGCG (50, 100, and 200 mg/kg) by oral gavage for 28 days. On the last day of experiment, the forced swimming exercise was performed and corresponding biochemical parameters were measured.

Results: The data showed that EGCG prolonged exhaustive swimming time, decreasing the levels of blood lactic acid, serum urea nitrogen, serum creatine kinase and malondialdehyde, which were accompanied by corresponding increase in liver and muscle glycogen contents, and superoxide dismutase, catalase, and glutathione peroxidase activities.

Conclusions: This study indicated that EGCG had an anti-fatigue effect.

Summary: EGCG significantly prolonged exhaustive swimming time and decreased the levels of BLA, SUN, SCK and MDA, which were accompanied by corresponding increases in liver and muscle glycogen contents, and SOD, CAT, and GPx activities.EGCG can be used to design nutraceutical supplements aimed to facilitate recovery from fatigue and attenuate exhaustive exercise-induced oxidative damage. Abbreviations used: EGCG: (-)-Epigallocatechin-3-gallate, ROS: reactive oxygen species, BLA: blood lactic acid, SUN: serum urea nitrogen, SOD: superoxide dismutase, GPx: glutathione peroxidase, CAT: catalase, SCK: serum creatine kinase, MDA: malondialdehyde, C: control, LET: Low-dose EGCG-treated, MET: Middle-dose EGCG-treated, HET: High-dose EGCG-treated, GTE: green tea extract.

Keywords: (-)-Epigallocatechin-3-gallate; anti-fatigue; biochemical parameters; forced swimming exercise; mice.

Conflict of interest statement

There are no conflicts of interest

Figures

None
Figure 1
Figure 1
Effects of EGCG on exhaustive swimming times of mice. Data are expressed as mean ± SD. *P < 0.05 compared with C group; #P< 0.05 compared with LET group
Figure 2
Figure 2
Effects of EGCG on some blood biochemical parameters levels of mice. Data are expressed as mean ± SD. *P < 0.05 compared with C group; #P<0.05 compared with LET group
Figure 3
Figure 3
Effects of EGCG on liver and muscle glycogen contents of mice. Data are expressed as mean ± SD. *P < 0.05 compared with C group; #P<0.05 compared with LET group
Figure 4
Figure 4
Effects of EGCG on superoxide dismutase activities in liver and muscle of mice. Data are expressed as mean ± SD. *P < 0.05 compared with C group; #P<0.05 compared with LET group
Figure 5
Figure 5
Effects of EGCG on glutathione peroxidase activities in liver and muscle of mice. Data are expressed as mean ± SD. *P < 0.05 compared with C group; #P < 0.05 compared with LET group.
Figure 6
Figure 6
Effects of EGCG on catalase activities in liver and muscle of mice. Data are expressed as mean ± SD. *P < 0.05 compared with C group; #P<0.05 compared with LET group
Figure 7
Figure 7
Effects of EGCG on malondialdehyde levels in liver and muscle of mice. Data are expressed as mean ± SD. *P < 0.05 compared with C group; #P<0.05 compared with LET group.

Similar articles

Cited by 1 PubMed Central articles

References

    1. Evans WJ, Lambert CP. Physiological basis of fatigue. Am J Phys Med Rehabil. 2007;86:S29–46. - PubMed
    1. Huang CC, Hsu MC, Huang WC, Yang HR, Hou CC. Triterpenoid-rich extract from Antrodia camphorata improves physical fatigue and exercise performance in mice. Evid Based Complement Alternat Med. 2012;364741:1–7. - PMC - PubMed
    1. Ataka S, Tanaka M, Nozaki S, Mizuma H, Mizuno K, Tahara T, et al. Effects of Applephenon and ascorbic acid on physical fatigue. Nutrition. 2007;23:419–23. - PubMed
    1. Su KY, Yu CY, Chen YW, Huang YT, Chen CT, Wu HF, et al. Rutin, a flavonoid and principal component of Saussurea involucrata, attenuates physical fatigue in a forced swimming mouse model. Int J Med Sci. 2014;11:528–37. - PMC - PubMed
    1. Aguiló A, Tauler P, Fuentespina E, Tur JA, Córdova A, Pons A. Antioxidant response to oxidative stress induced by exhaustive exercise. Physiol Behav. 2005;31:1–7. - PubMed
Feedback