Hyperthermic chemotherapy intra-abdominal laparoscopic approach: development of a laparoscopic model using CO2 recirculation system and clinical translation in peritoneal carcinomatosis

Int J Hyperthermia. 2017 Sep;33(6):684-689. doi: 10.1080/02656736.2017.1302100. Epub 2017 Apr 2.


Introduction: Hyperthermic intraperitoneal chemotherapy (HIPEC) is an effective treatment for peritoneal carcinomatosis (PC). Laparoscopic surgery is performed in the treatment of colorectal and appendiceal cancer, and PC from diverse origin in selected patients. HIPEC management by laparoscopic approach after cytoreductive surgery (CRS) completed locoregional treatment of PC, and may be feasible and safe after appropriate patient selection.

Objective: Development of an experimental model of HIPEC by laparoscopic approach, with CO2 recirculation. Clinical translation in two patients with PC and low peritoneal cancer index.

Material and methods: We performed CRS in a porcine model of 5 pigs (35-38 kg) by laparoscopic approach. Laparoscopic HIPEC by CO2 recirculation system was performed; laparoscopic access was used for catheter input and output placement (Paclitaxel 175 mg/m2 for 60 min at 42 °C). The experimental variables were: blood gases, haemodynamic and intra-abdominal and central temperature. Clinical model application was performed in three cases with PC from colorectal origin.

Results: No statistically significant differences was found in blood gases, haemodynamic or temperature in the experimental study. In clinical study, there were no technical complications during laparoscopic-HIPEC approach, and we observed no changes in haemodynamic variables during the procedure.

Conclusions: CRS and HIPEC laparoscopic model by CO2 recirculation system is safe and feasible technique in selected patients, that include low PC index, local and accessible tumour recurrences or high-risk of PC tumours.

Keywords: Peritoneal carcinomatosis; minimally invasive HIPEC; minimally invasive cytoreduction.

MeSH terms

  • Adult
  • Aged
  • Animals
  • Antibiotics, Antineoplastic / therapeutic use*
  • Blood Gas Analysis
  • Carbon Dioxide / therapeutic use*
  • Combined Modality Therapy
  • Female
  • Hemodynamics
  • Humans
  • Hyperthermia, Induced*
  • Laparoscopy*
  • Male
  • Middle Aged
  • Mitomycin / therapeutic use*
  • Peritoneal Neoplasms / blood
  • Peritoneal Neoplasms / physiopathology
  • Peritoneal Neoplasms / surgery
  • Peritoneal Neoplasms / therapy*
  • Swine
  • Swine, Miniature


  • Antibiotics, Antineoplastic
  • Carbon Dioxide
  • Mitomycin