Jaboticaba berry peel intake prevents insulin-resistance-induced tau phosphorylation in mice

Mol Nutr Food Res. 2017 Oct;61(10). doi: 10.1002/mnfr.201600952. Epub 2017 Jul 3.


The hyperphosphorylation of microtubule-associated protein tau (tau) in the hippocampus can be caused by central and peripheral insulin resistance and these alterations are related to the development of tauopathies, such as Alzheimer's disease. In this study, we used a high-fat diet to induce obesity and insulin resistance in adult Swiss mice and checked whether supplementation with Myrciaria jaboticaba berry peel for 10 weeks could improve insulin sensitivity, learning/memory performance, and prevent tau phosphorylation in the hippocampus. Furthermore, adipocytokines, inflammatory markers, and oxidative stress were assessed. Myrciaria jaboticaba peel has phenolic compounds (e.g., cyanidin, ellagic acid), dietary fiber and carotenoids, which contribute to great antioxidant capacity. Supplementation of the high-fat diet with 4% M. jaboticaba peel prevented fat weight gain and reduced peripheral insulin resistance. The treated group also showed lower tau phosphorylation in the hippocampus corroborating better learning/memory performance in the Morris water maze test. Maintenance of neuronal viability, lower levels of hippocampal inflammatory markers, and improved brain antioxidant defenses were also related to the consumption of M. jaboticaba peel. These findings contribute to a better understanding of how a high-fat diet supplemented with jaboticaba berry peel counteracts the impairment of cognitive functions caused by high-fat diet intake and diet-induced insulin resistance.

Keywords: Antioxidants; Bioactive compounds; Cognition; Obesity; Oxidative stress.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthocyanins / pharmacology
  • Biomarkers / blood
  • Carotenoids / pharmacology
  • Cognition / drug effects
  • Cytokines / blood
  • Diet, High-Fat
  • Dietary Fiber / pharmacology
  • Ellagic Acid / pharmacology
  • Fruit / chemistry*
  • Hippocampus / drug effects
  • Hippocampus / metabolism
  • Insulin / blood
  • Insulin Resistance*
  • Male
  • Memory / drug effects
  • Mice
  • Myrtaceae / chemistry*
  • Obesity / prevention & control
  • Oxidative Stress / drug effects
  • Phosphorylation
  • Weight Gain
  • tau Proteins / genetics
  • tau Proteins / metabolism*


  • Anthocyanins
  • Biomarkers
  • Cytokines
  • Dietary Fiber
  • Insulin
  • Mapt protein, mouse
  • tau Proteins
  • Ellagic Acid
  • Carotenoids
  • cyanidin