Obstructive sleep apnea: the effect of bariatric surgery after 12 months. A prospective multicenter trial

Sleep Med. 2017 Jul;35:85-90. doi: 10.1016/j.sleep.2016.12.017. Epub 2017 Jan 12.

Abstract

Background: Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder, particularly in bariatric patients. It is known to be tightly linked with metabolic abnormalities and cardiovascular morbidity. Obesity is the most noteworthy individual risk factor for OSA. The aim of this study was to investigate the effect of a laparoscopic Roux-en-Y gastric bypass (LRYGB) on OSA one year after surgery.

Methods: In this prospective multicenter study standard overnight cardiorespiratory recording was conducted 12 months after bariatric surgery in 132 patients who had OSA in the baseline recording prior to the operation. The main outcome measures were changes in the prevalence of OSA and apnea-hypopnea index (AHI). In addition, the changes in anthropometric and demographic measurements including weight, body mass index (BMI), and waist and neck circumference were evaluated. A sleep symptom questionnaire was administered at baseline and at 12 months.

Results: The prevalence of OSA decreased from 71% at baseline to 44% at 12 months after surgery (p < 0.001). OSA was cured in 45% and cured or improved in 78% of the patients, but moderate or severe OSA still persisted in 20% of the patients after the operation. De novo OSA occurred in eight percent of the patients, and total AHI decreased from 27.8 events/h to 9.9 events/h (p < 0.001).

Conclusions: LRYGB is effective in treating OSA. However, the findings demonstrate that a postoperative cardiorespiratory recording is needed in order to identify the patients with persistent moderate to severe OSA after the operation.

Clinical trial registration: ClinalTrials.gov; No.: NCT01080404; URL: www.clinicaltrials.gov.

Keywords: Apnea–hypopnea index; Bariatric surgery; Effect of bariatric surgery; Metabolic surgery; Obesity surgery; Obstructive sleep apnea.

Publication types

  • Clinical Trial
  • Multicenter Study

MeSH terms

  • Comorbidity
  • Female
  • Follow-Up Studies
  • Gastric Bypass*
  • Humans
  • Laparoscopy
  • Male
  • Middle Aged
  • Obesity / complications*
  • Obesity / epidemiology
  • Obesity / surgery*
  • Prevalence
  • Severity of Illness Index
  • Sleep Apnea, Obstructive / complications*
  • Sleep Apnea, Obstructive / epidemiology
  • Sleep Apnea, Obstructive / surgery
  • Surveys and Questionnaires
  • Treatment Outcome
  • Weight Loss

Associated data

  • ClinicalTrials.gov/NCT01080404