[Human papillomavirus nonavalent vaccine. Update 2017]

Semergen. May-Jun 2017;43(4):265-276. doi: 10.1016/j.semerg.2017.04.010. Epub 2017 May 23.
[Article in Spanish]


Human papillomavirus (HPV) is the causative agent of 5% of human cancers. HPV infection is necessary for the development of cervical cancer and is responsible of a variable percentage of cancers of anus, vulva, vagina, penis, and oropharynx. Since 2007, 2 vaccines against HPV have been commercially available in Spain: bivalent (HPV types 16/18), and tetravalent (HPV types 6/11/16/18). In order to extend the protection afforded by HPV vaccines, a clinical program was launched in 2006 for the new nonavalent vaccine, including 9 HPV types (6/11/16/18/31/33/45/52/58). These types are responsible for 90% of cervical cancers, 82% of high-grade ano-genital pre-cancerous lesions, and 90% of genital warts. The purpose of this publication is to provide healthcare professionals with the scientific evidence that supports the new vaccine, as well as the clinical value that it offers in our environment.

Keywords: Cervical cancer; Cáncer cervical; Human papillomavirus; Lesiones precancerosas; Nonavalent vaccine; Pre-cancerous lesions; Vacuna nonavalente; Virus del papiloma humano.

MeSH terms

  • Drug Approval
  • Female
  • Humans
  • Neoplasms / pathology
  • Neoplasms / prevention & control
  • Neoplasms / virology
  • Papillomaviridae / isolation & purification
  • Papillomavirus Infections / complications
  • Papillomavirus Infections / prevention & control*
  • Papillomavirus Vaccines / administration & dosage*
  • Spain
  • Uterine Cervical Neoplasms / prevention & control*
  • Uterine Cervical Neoplasms / virology


  • Papillomavirus Vaccines