Chronic Periodontitis Does Not Impact Serum Levels of Prostate-specific Antigen

Anticancer Res. 2017 Jun;37(6):3163-3167. doi: 10.21873/anticanres.11675.

Abstract

Background/aim: Chronic periodontitis (CP) has already been associated with altered PSA values in men undergoing biopsy. This study addressed the impact of CP treatment on PSA screening.

Patients and methods: Fifty-two asymptomatic men presenting for CP treatment were prospectively enrolled. Total (t)PSA, free (f)PSA and %PSA were determined (n=47) before and after therapy. Pre- and post-therapy values were correlated pairwise regarding patients and dental characteristics.

Results: Median age was 54 years (SD=±7.7 years) and mean tPSA was 1.3 ng/ml (±1.9 ng/ml). tPSA and fPSA correlated linearly and positively with age (p<0.002). After stratification by age, tPSA/fPSA remained significantly lower in smokers (p<0.05). No other patient or dental factor was associated with tPSA, fPSA, %PSA. CP therapy had no effect on PSA reduction and did not affect indication for biopsy.

Conclusion: The potential influence of CP on PSA testing seems to be excludable in asymptomatic men.

Keywords: Chronic periodontitis; inflammation; mass screening; prostate cancer; prostate-specific antigen.

MeSH terms

  • Age Factors
  • Asymptomatic Diseases
  • Chronic Periodontitis / blood*
  • Chronic Periodontitis / diagnosis
  • Chronic Periodontitis / therapy
  • Humans
  • Kallikreins / blood*
  • Linear Models
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Prospective Studies
  • Prostate-Specific Antigen / blood*
  • Prostatic Neoplasms / blood*
  • Prostatic Neoplasms / diagnosis
  • Smoking / blood
  • Treatment Outcome

Substances

  • KLK3 protein, human
  • Kallikreins
  • Prostate-Specific Antigen