Novel and Experimental Therapies in Chronic Pancreatitis

Dig Dis Sci. 2017 Jul;62(7):1751-1761. doi: 10.1007/s10620-017-4604-0. Epub 2017 May 27.


Chronic pancreatitis (CP) is a progressive inflammatory disease of the pancreas. The currently available treatment of CP is aimed at controlling symptoms and managing complications. Unfortunately, no specific treatment is available to halt the progression of the disease process because the pathophysiological perturbations in CP are not well understood. In this review, we discuss various therapeutic targets and investigational agents acting on these targets. Among these, therapies modulating immune cells and those acting on pancreatic stellate cells appear promising and may translate into clinical benefit in near future. However, these experimental therapies are mostly in animal models and they do not recapitulate all aspects of human disease. Still they may be beneficial in developing effective therapeutic modalities to curb inflammation in chronic pancreatitis.

Keywords: Chronic pancreatitis; Experimental therapy; Immune system; Pancreatic stellate cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Gene Expression Regulation
  • Humans
  • Immunotherapy / methods*
  • Pancreatic Stellate Cells
  • Pancreatitis, Chronic / immunology
  • Pancreatitis, Chronic / physiopathology
  • Pancreatitis, Chronic / therapy*