Safety Assessment of Amino Acid Alkyl Amides as Used in Cosmetics

Int J Toxicol. 2017 May/Jun;36(1_suppl):17S-56S. doi: 10.1177/1091581816686048.

Abstract

The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the product use, formulation, and safety data of 115 amino acid alkyl amides, which function as skin and hair conditioning agents and as surfactants-cleansing agents in personal care products. Safety test data on dermal irritation and sensitization for the ingredients with the highest use concentrations, lauroyl lysine and sodium lauroyl glutamate, were reviewed and determined to adequately support the safe use of the ingredients in this report. The Panel concluded that amino acid alkyl amides are safe in the present practices of use and concentration in cosmetics, when formulated to be nonirritating.

Keywords: amino acid alkyl amides; cosmetics; safety.

MeSH terms

  • Amides / chemistry
  • Amides / pharmacokinetics
  • Amides / toxicity*
  • Amino Acids / chemistry
  • Amino Acids / pharmacokinetics
  • Amino Acids / toxicity*
  • Animals
  • Consumer Product Safety
  • Cosmetics / chemistry
  • Cosmetics / pharmacokinetics
  • Cosmetics / toxicity*
  • Humans
  • Risk Assessment
  • Surface-Active Agents / chemistry
  • Surface-Active Agents / pharmacokinetics
  • Surface-Active Agents / toxicity*
  • Toxicity Tests

Substances

  • Amides
  • Amino Acids
  • Cosmetics
  • Surface-Active Agents