Adherence to Guidelines for Screening and Medication Use: Mortality and Onset of Major Macrovascular Complications in Elderly Persons With Diabetes Mellitus

J Aging Health. 2018 Apr;30(4):503-520. doi: 10.1177/0898264316684270. Epub 2016 Dec 21.

Abstract

Objective: The objective of this study is to investigate relationships between adherence to recommended screening and medication use and severe macrovascular complications and all-cause mortality among persons aged above 68 years with diabetes mellitus (DM).

Method: Data came from a 5% Medicare claims sample of beneficiaries initially diagnosed with DM during 2006-2008; follow-up was up to 7 years.

Results: Adherence to screening guidelines led to reduced mortality-hazard ratio (HR) = 0.57, 95% confidence interval [CI] = [0.56, 0.58]; congestive heart failure [CHF], HR = 0.89, CI = [0.87, 0.91]; acute myocardial infarction [AMI], HR = 0.90, CI = [0.85, 0.95]; and stroke/transient ischemic attack [Stroke/TIA], HR = 0.92, CI = [0.87, 0.97]-during follow-up. Recommended medication use led to lower mortality: HR = 0.72, CI = [0.70, 0.73]; CHF, HR = 0.67, CI = [0.66, 0.69]; AMI, HR = 0.68, CI = [0.65, 0.71]; and Stroke/TIA, HR = 0.79, CI = [0.76, 0.83].

Discussion: Elderly persons newly diagnosed with diabetes who adhered to recommended care experienced reduced risk of mortality and severe macrovascular complications.

Keywords: acute myocardial infarction; adherence; congestive heart failure; diabetes mellitus; stroke.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Diabetes Complications / epidemiology*
  • Diabetes Complications / prevention & control
  • Diabetes Mellitus / diagnosis
  • Diabetes Mellitus / drug therapy
  • Diabetes Mellitus / epidemiology*
  • Female
  • Guideline Adherence*
  • Humans
  • Hypoglycemic Agents / therapeutic use*
  • Male
  • Mass Screening / standards*
  • Medicare / statistics & numerical data
  • Morbidity / trends
  • Survival Rate / trends
  • United States / epidemiology

Substances

  • Hypoglycemic Agents