Effects of mammarenavirus infection (Wēnzhōu virus) on the morphology of Rattus exulans

Infect Genet Evol. 2018 Sep;63:404-409. doi: 10.1016/j.meegid.2017.05.023. Epub 2017 May 26.

Abstract

The circulation of mammarenaviruses in rodent populations of the Mekong region has recently been established, with a genetic variant of Wēnzhōu virus, Cardamones virus, detected in two Rattus species. This study tests the potential teratogenic effects of Wēnzhōu infection on the development of a Murid rodent, Rattus exulans. Using direct virus detection, morphological records and comparative analyses, a link was demonstrated between host infection status and host morphologies (the spleen irrespective of weight, the skull shape and the cranial cavity volume) at the level of the individual (females only). This study demonstrates that mammarenavirus infections can impact natural host physiology and/or affect developmental processes. The presence of an infecting micro-parasite during the development of the rat may lead to a physiological trade-off between immunity and brain size. Alternatively, replication of virus in specialized organs can result in selective morphologic abnormalities and lesions.

Keywords: Host morphologies; Mammarenavirus; Rattus exulans; Teratogenic effects; Wēnzhōu virus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arenaviridae / pathogenicity*
  • Arenaviridae / physiology
  • Arenaviridae Infections / diagnostic imaging
  • Arenaviridae Infections / pathology
  • Arenaviridae Infections / veterinary*
  • Arenaviridae Infections / virology*
  • Brain / growth & development
  • Brain / virology
  • Cambodia
  • Female
  • Host-Pathogen Interactions*
  • Kidney / growth & development
  • Kidney / virology
  • Liver / growth & development
  • Liver / virology
  • Lung / growth & development
  • Lung / virology
  • Male
  • Organ Size
  • Rats
  • Rodent Diseases / diagnostic imaging
  • Rodent Diseases / pathology
  • Rodent Diseases / virology*
  • Sex Factors
  • Skull / growth & development
  • Skull / virology
  • Spleen / growth & development
  • Spleen / virology

Supplementary concepts

  • Wenzhou mammarenavirus