Differential neuronal susceptibility and apoptosis in congenital Zika virus infection

Ann Neurol. 2017 Jul;82(1):121-127. doi: 10.1002/ana.24968.

Abstract

To characterize the mechanism of Zika virus (ZIKV)-associated microcephaly, we performed immunolabeling on brain tissue from a 20-week fetus with intrauterine ZIKV infection. Although ZIKV demonstrated a wide range of neuronal and non-neuronal tropism, the infection rate was highest in intermediate progenitor cells and immature neurons. Apoptosis was observed in both infected and uninfected bystander cortical neurons, suggesting a role for paracrine factors in induction of neuronal apoptosis. Our results highlight differential neuronal susceptibility and neuronal apoptosis as potential mechanisms in the development of ZIKV-associated microcephaly, and may provide insights into the design and best timing of future therapy. Ann Neurol 2017;82:121-127.

MeSH terms

  • Apoptosis
  • Brain / pathology
  • Brain / virology
  • Disease Susceptibility
  • Fetus / pathology*
  • Fetus / virology*
  • Humans
  • Neurons / pathology*
  • Neurons / virology*
  • Zika Virus Infection / pathology*
  • Zika Virus Infection / virology