Dose-dependence of transient respiratory motion artifacts on gadoxetic acid-enhanced arterial phase MR images

J Magn Reson Imaging. 2018 Feb;47(2):433-438. doi: 10.1002/jmri.25764. Epub 2017 May 26.


Purpose: To compare the occurrence of transient respiratory motion (TM) artifacts between 0.05 mmol/kg and 0.025 mmol/kg gadoxetic-acid on arterial phase MRI intra-individually for evaluating dose-dependence of gadoxetic acid.

Materials and methods: This retrospective study involved 91 patients who underwent dynamic MRI at 1.5T at different times, one time with 0.05 mmol/kg and the other 0.025 mmol/kg gadoxetic-acid. Examinations with 0.05 mmol/kg totaled 91 scans, and examinations with 0.025 mmol/kg totaled 375 scans (due to multiple exams for several patients). The scan with 0.025 mmol/kg closest in time to the 0.05 mmol/kg scan was selected to minimize temporal effects. Two radiologists graded TM artifacts in the arterial phase images using a four-point scale: no, mild, moderate, and severe artifacts. Results were compared between the two protocols (0.05 mmol/kg versus all 0.025 mmol/kg and 0.05 mmol/kg versus selected 0.025 mmol/kg), and the odds ratio for moderate-to-severe artifacts was calculated.

Results: Significantly more TM artifacts were observed in the double dose (16/91 [17%]) scans compared with either all (17/375 [4%]; P < 0.01) or selected (3/91 [3%]; P = 0.01) standard dose scans. The odds ratio of the moderate-to-severe artifacts with the higher dose was 4.99-5.33.

Conclusion: There appears to be dose-dependence of gadoxetic-acid and the occurrence of TM artifacts.

Level of evidence: 3 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;47:433-438.

Keywords: arterial phase image; dose dependence; gadoxetic acid; magnetic resonance imaging; transient motion artifact.

MeSH terms

  • Abdominal Cavity / diagnostic imaging*
  • Aged
  • Artifacts*
  • Contrast Media*
  • Dose-Response Relationship, Drug
  • Female
  • Gadolinium DTPA*
  • Humans
  • Image Enhancement / methods*
  • Magnetic Resonance Imaging / methods*
  • Male
  • Motion
  • Retrospective Studies


  • Contrast Media
  • gadolinium ethoxybenzyl DTPA
  • Gadolinium DTPA