Effect of enalapril treatment on progression of the nephrotoxic serum nephritis model of renal failure in the rat

Clin Exp Pharmacol Physiol. 1988 Feb;15(2):131-6. doi: 10.1111/j.1440-1681.1988.tb01054.x.

Abstract

1. Nephrotoxic serum nephritis was induced immunologically in uninephrectomized Sprague-Dawley rats (n = 24). One-half were assigned randomly to treatment with enalapril (5 mg/kg per 24 h). 2. Untreated rats (n = 12) developed a progressive fall in creatinine clearance, a progressive rise in systolic blood pressure and marked proteinuria over a 6 week period. The mortality rate was 42% at 5 weeks and 66% at 6 weeks. 3. Enalapril-treated rats (n = 12) had no significant reduction in systolic blood pressure, and a similar reduction in creatinine clearance to that in untreated rats. Mortality was 50% at 5 weeks, and 92% at 6 weeks. 4. Proteinuria but not the blood pressure rise was significantly reduced by enalapril treatment. 5. Converting enzyme inhibitors may have a specific role in the treatment of nephritic diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Pressure / drug effects
  • Creatinine / blood
  • Enalapril / pharmacology*
  • Female
  • Glomerular Filtration Rate / drug effects
  • Kidney Failure, Chronic / chemically induced
  • Kidney Failure, Chronic / mortality
  • Kidney Failure, Chronic / physiopathology*
  • Nephritis / chemically induced*
  • Proteinuria / chemically induced
  • Rats
  • Rats, Inbred Strains

Substances

  • Enalapril
  • Creatinine