Medication compliance and clinical outcomes of fixed-dose combinations vs free combinations of an angiotensin II receptor blocker and a calcium channel blocker in hypertension treatment

Ying-Chang Tung; Yu-Chang Huang; Lung-Sheng Wu; Chee-Jen Chang; Pao-Hsien Chu

doi:10.1111/jch.13035

Medication compliance and clinical outcomes of fixed-dose combinations vs free combinations of an angiotensin II receptor blocker and a calcium channel blocker in hypertension treatment

J Clin Hypertens (Greenwich). 2017 Oct;19(10):983-989. doi: 10.1111/jch.13035. Epub 2017 May 30.

Authors

Ying-Chang Tung¹, Yu-Chang Huang¹, Lung-Sheng Wu¹, Chee-Jen Chang², Pao-Hsien Chu^{1

3

4}

Affiliations

¹ Department of Cardiology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan.
² Clinical Informatics and Medical Statistics Research Center, College of Medicine, Chang Gung University, Taipei, Taiwan.
³ Healthcare Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan.
⁴ Heart Failure Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan.

Abstract

Using the National Health Insurance Research Database of Taiwan, the authors identified 1136 patients taking fixed-dose combination and 4544 patients taking free combinations of an angiotensin II receptor blocker and a dihydropyridine calcium channel blocker from January 2009 to December 2012. At a mean follow-up of 2.1 years, the fixed-dose combination was associated with improved medication adherence and persistence and better survival free from major adverse cardiac events and hospitalization for heart failure compared with the free combination regimens.

Keywords: angiotensin II receptor blocker; dihydropyridine calcium channel blocker; fixed-dose combination; hypertension; major adverse cardiac event.

Publication types

Comparative Study

MeSH terms

Aged
Angiotensin Receptor Antagonists / administration & dosage
Angiotensin Receptor Antagonists / adverse effects
Angiotensin Receptor Antagonists / therapeutic use*
Angiotensin-Converting Enzyme Inhibitors / administration & dosage
Angiotensin-Converting Enzyme Inhibitors / adverse effects
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Antihypertensive Agents / therapeutic use
Blood Pressure / drug effects
Calcium Channel Blockers / administration & dosage
Calcium Channel Blockers / adverse effects
Calcium Channel Blockers / therapeutic use*
Cardiovascular Diseases / epidemiology
Cardiovascular Diseases / mortality
Cardiovascular Diseases / prevention & control
Drug Therapy, Combination / methods*
Female
Humans
Hypertension / drug therapy*
Hypertension / epidemiology
Male
Medication Adherence / statistics & numerical data*
Middle Aged
Retrospective Studies
Survival Analysis
Taiwan / epidemiology
Treatment Outcome

Substances

Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors
Antihypertensive Agents
Calcium Channel Blockers