Consumption of Dairy Yogurt Containing Lactobacillus paracasei ssp. paracasei, Bifidobacterium animalis ssp. lactis and Heat-Treated Lactobacillus plantarum Improves Immune Function Including Natural Killer Cell Activity

Nutrients. 2017 May 31;9(6):558. doi: 10.3390/nu9060558.


The aim of this study was to investigate the impact of consuming dairy yogurt containing Lactobacillus paracasei ssp. paracasei (L. paracasei), Bifidobacterium animalis ssp. lactis (B. lactis) and heat-treated Lactobacillus plantarum (L. plantarum) on immune function. A randomized, open-label, placebo-controlled study was conducted on 200 nondiabetic subjects. Over a twelve-week period, the test group consumed dairy yogurt containing probiotics each day, whereas the placebo group consumed milk. Natural killer (NK) cell activity, interleukin (IL)-12 and immunoglobulin (Ig) G1 levels were significantly increased in the test group at twelve weeks compared to baseline. Additionally, the test group had significantly greater increases in serum NK cell activity and interferon (IFN)-γ and IgG1 than placebo group. Daily consumption of dairy yogurt containing L. paracasei, B. lactis and heat-treated L. plantarum could be an effective option to improve immune function by enhancing NK cell function and IFN-γ concentration ( NCT03051425).

Keywords: IFN-γ; NK cell activity; immune function; probiotics.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Bifidobacterium animalis*
  • Blood Glucose / metabolism
  • Body Mass Index
  • Cholesterol / blood
  • Diet
  • Double-Blind Method
  • Exercise
  • Female
  • Follow-Up Studies
  • Humans
  • Immunoglobulin G / blood
  • Interferon-gamma / blood
  • Interleukin-12 / blood
  • Killer Cells, Natural / microbiology*
  • Lacticaseibacillus paracasei*
  • Lactobacillus plantarum*
  • Leukocytes, Mononuclear / metabolism
  • Male
  • Middle Aged
  • Probiotics*
  • Serum Albumin / metabolism
  • Triglycerides / blood
  • Yogurt / microbiology*


  • Blood Glucose
  • Immunoglobulin G
  • Serum Albumin
  • Triglycerides
  • Interleukin-12
  • Interferon-gamma
  • Cholesterol

Associated data