Quantitative proteomics: challenges and opportunities in basic and applied research

Nat Protoc. 2017 Jul;12(7):1289-1294. doi: 10.1038/nprot.2017.040. Epub 2017 Jun 1.

Abstract

In this Perspective, we discuss developments in mass-spectrometry-based proteomic technology over the past decade from the viewpoint of our laboratory. We also reflect on existing challenges and limitations, and explore the current and future roles of quantitative proteomics in molecular systems biology, clinical research and personalized medicine.

MeSH terms

  • Clinical Laboratory Techniques / methods
  • Humans
  • Mass Spectrometry / methods*
  • Proteomics / methods*
  • Proteomics / trends
  • Systems Biology / methods