Self-powered therapeutic release from conducting polymer/graphene oxide films on magnesium

Nanomedicine. 2018 Oct;14(7):2495-2503. doi: 10.1016/j.nano.2017.02.021. Epub 2017 May 29.

Abstract

Magnesium's complete in vivo degradation is appealing for medical implant applications. Rapid corrosion and hydrogen bubble generation along with inflammatory host tissue response have limited its clinical use. Here we electropolymerized a poly (3,4-ethylenedioxythiophene) (PEDOT) and graphene oxide (GO) film directly on Mg surface. GO acted as nano-drug carrier to carry anti-inflammatory drug dexamethasone (Dex). PEDOT/GO/Dex coatings improved Mg corrosion resistance and decreased the rate of hydrogen production. Dex could be released driven by the electrical current generated from Mg corrosion. The anti-inflammatory activity of the released Dex was confirmed in microglia cultures. This PEDOT/GO/Dex film displayed the ability to both control Mg corrosion and act as an on demand release coating that delivers Dex at the corrosion site to minimize detrimental effects of corrosion byproducts. Such multi-functional smart coating will improve the clinical use of Mg implants. Furthermore, the PEDOT/GO/Drug/Mg system may be developed into self-powered implantable drug delivery devices.

Keywords: Conducting polymer; Corrosion; Dexamethasone; Graphene; Magnesium; On demand release.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Absorbable Implants
  • Animals
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / pharmacology
  • Bridged Bicyclo Compounds, Heterocyclic / chemistry
  • Cells, Cultured
  • Coated Materials, Biocompatible / chemistry*
  • Corrosion
  • Delayed-Action Preparations
  • Dexamethasone / chemistry
  • Dexamethasone / pharmacology*
  • Drug Liberation*
  • Graphite / chemistry*
  • Magnesium / chemistry*
  • Microglia / drug effects*
  • Microglia / metabolism
  • Polymers / chemistry*
  • Rats
  • Surface Properties

Substances

  • Anti-Inflammatory Agents
  • Bridged Bicyclo Compounds, Heterocyclic
  • Coated Materials, Biocompatible
  • Delayed-Action Preparations
  • Polymers
  • poly(3,4-ethylene dioxythiophene)
  • Graphite
  • Dexamethasone
  • Magnesium