Myocarditis in auto-immune or auto-inflammatory diseases

Autoimmun Rev. 2017 Aug;16(8):811-816. doi: 10.1016/j.autrev.2017.05.021. Epub 2017 May 29.


Myocarditis is a major cause of heart disease in young patients and a common precursor of heart failure due to dilated cardiomyopathy. Some auto-immune and/or auto-inflammatory diseases may be accompanied by myocarditis, such as sarcoidosis, Behçet's disease, eosinophilic granulomatosis with polyangiitis, myositis, and systemic lupus erythematosus. However, data concerning myocarditis in such auto-immune and/or auto-inflammatory diseases are sparse. New therapeutic strategies should better target the modulation of the immune system, depending on the phase of the disease and the type of underlying auto-immune and/or auto-inflammatory disease.

Keywords: Autoimmune diseases; Myocarditis.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / complications*
  • Cardiomyopathy, Dilated / complications
  • Connective Tissue Diseases / complications
  • Hereditary Autoinflammatory Diseases / complications
  • Humans
  • Lupus Erythematosus, Systemic / complications
  • Myocarditis / etiology*
  • Myositis / complications
  • Sarcoidosis / complications
  • Vascular Diseases / complications

Supplementary concepts

  • Antisynthetase syndrome