Reversibility of cyclosporin nephrotoxicity after three months' treatment

Lancet. 1985 Jan 19;1(8421):128-30. doi: 10.1016/s0140-6736(85)91902-6.


86 renal allograft recipients were randomly assigned to cyclosporin (Cy) for 90 days followed by azathioprine and prednisolone (Aza and P), or to Aza and P from day 0, as part of the second Oxford trial of short-term Cy use. All 62 patients whose grafts functioned for at least 120 days were included in this study. Serum creatinine was significantly higher in Cy-treated patients than in control patients from day 28 to day 90. Serum uric acid was also significantly higher in Cy-treated patients over the same period. Both creatinine and uric acid fell to the level of the control group after conversion to Aza and P. Serum uric acid was significantly higher for a given level of creatinine during Cy treatment than in either the control patients or the Cy-treated patients after their treatment had been changed to Aza and P. These data imply that Cy affects both the glomerular filtration rate and renal tubular function but that these effects are largely reversible.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azathioprine / administration & dosage
  • Azathioprine / therapeutic use
  • Clinical Trials as Topic
  • Creatinine / blood
  • Cyclosporins / administration & dosage
  • Cyclosporins / adverse effects*
  • Cyclosporins / therapeutic use
  • Drug Administration Schedule
  • Graft Survival / drug effects
  • Humans
  • Kidney / drug effects*
  • Kidney / physiology
  • Kidney Transplantation
  • Prednisolone / administration & dosage
  • Prednisolone / therapeutic use
  • Random Allocation
  • Time Factors
  • Uric Acid / blood


  • Cyclosporins
  • Uric Acid
  • Prednisolone
  • Creatinine
  • Azathioprine