Plasminogen Activator Inhibitor-1 Is a Marker and a Mediator of Senescence

Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1446-1452. doi: 10.1161/ATVBAHA.117.309451. Epub 2017 Jun 1.


PAI-1 (plasminogen activator inhibitor-1) is a member of the evolutionarily conserved serine protease inhibitor family and a potent and rapid-acting inhibitor of both of the mammalian plasminogen activators. Organismal homeostasis requires physiological levels of endogenous PAI-1, and increased PAI-1 production guides the onset and progression of numerous human diseases and contributes to the multimorbidity of aging. Both chronological and stress-induced accelerated aging are associated with cellular senescence and accompanied by marked increases in PAI-1 expression in tissues. Recent studies suggest that PAI-1 is not only a marker but also a key mediator of cellular senescence and organismal aging. Here, we review the significance of PAI-1 as a bonafide marker, as well as a critical mediator, of cellular senescence associated with aging and aging-related pathologies.

Keywords: aging; arteriosclerosis; endothelial dysfunction; plasminogen activator inhibitor-1; thrombosis; transforming growth factor-β.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / metabolism*
  • Aging / pathology
  • Animals
  • Biomarkers / metabolism
  • Cellular Senescence*
  • Disease
  • Health Status
  • Humans
  • Plasminogen Activator Inhibitor 1 / metabolism*
  • Signal Transduction


  • Biomarkers
  • Plasminogen Activator Inhibitor 1
  • SERPINE1 protein, human