Alpha-globin gene organisation and prenatal diagnosis of alpha-thalassaemia in Chinese

Lancet. 1985 Feb 9;1(8424):304-7. doi: 10.1016/s0140-6736(85)91081-5.


DNA samples from 60 Chinese patients with haemoglobin H disease were analysed by restricted endonuclease mapping to determine the patterns of alpha-globin gene organisation and the distribution of these patterns in China. Restriction endonuclease analysis and rapid micro-DNA hybridisation on nitrocellulose membranes were also used to analyse DNA from amniotic fluid cells or from chorionic villi in 7 pregnancies at risk of haemoglobin Barts hydrops fetalis, in 1 at risk of haemoglobin H disease, and 1 at risk of both disorders.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amniotic Fluid / cytology
  • Autoradiography
  • China
  • Chorionic Villi / ultrastructure
  • Chromosome Mapping
  • DNA Restriction Enzymes
  • Female
  • Genes
  • Globins / genetics*
  • Humans
  • Infant, Newborn
  • Pregnancy
  • Prenatal Diagnosis*
  • Thalassemia / diagnosis*
  • Thalassemia / genetics


  • Globins
  • DNA Restriction Enzymes