Dietary Vitamin D and Calcium and Risk of Colorectal Cancer: A 19-year Prospective Study in Men

Lancet. 1985 Feb 9;1(8424):307-9. doi: 10.1016/s0140-6736(85)91082-7.

Abstract

Mortality rates from colon cancer in the USA are highest in populations exposed to the least amounts of natural sunlight; differences in endogenous vitamin D production and calcium absorption could be responsible. To investigate this possibility, the association of dietary vitamin D and calcium with 19-year risk of colorectal cancer was examined in 1954 men who had completed detailed, 28-day dietary histories in the period 1957-59. Risk of colorectal cancer was inversely correlated with dietary vitamin D and calcium. In the quartiles of a combined index of dietary vitamin D and calcium, from lowest to highest, observed risks of colorectal cancer were 38.9, 24.5, 22.5, and 14.3/1000 population. This association remained significant after adjustment for age, daily cigarette consumption, body mass index, ethanol consumption, and percentage of calories obtained from fat.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Calcium, Dietary / administration & dosage*
  • Colonic Neoplasms / epidemiology
  • Colonic Neoplasms / etiology*
  • Diet*
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Random Allocation
  • Rectal Neoplasms / epidemiology
  • Rectal Neoplasms / etiology*
  • Risk
  • Vitamin D / administration & dosage*

Substances

  • Calcium, Dietary
  • Vitamin D