Probiotics for the Prevention of Nosocomial Diarrhea in Children

J Pediatr Gastroenterol Nutr. 2018 Jan;66(1):3-9. doi: 10.1097/MPG.0000000000001637.


This document provides recommendations developed by the ESPGHAN Working Group on Probiotics and Prebiotics on the role of probiotics in the prevention of nosocomial diarrhea in children based on a systematic review of previously completed systematic reviews and of subsequently published randomized controlled trials. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation guidelines. Recommendations were given only if at least 2 randomized controlled trials examined the same probiotic strain. Based on currently available evidence the Working Group recommends using Lactobacillus rhamnosus GG if the use of probiotics for preventing nosocomial diarrhea in children is considered.

Publication types

  • Practice Guideline

MeSH terms

  • Child
  • Cross Infection / prevention & control*
  • Diarrhea / microbiology
  • Diarrhea / prevention & control*
  • Humans
  • Lactobacillus rhamnosus*
  • Probiotics / therapeutic use*