Mitotic Bookmarking: Maintaining the Stem Cell Identity during Mitosis

Cell Stem Cell. 2017 Jun 1;20(6):741-742. doi: 10.1016/j.stem.2017.05.002.


In Cell Reports, Liu et al. (2017) investigate mechanisms for how pluripotent stem cells maintain their identity during cell division. They show that the histone mark H3K27ac and pluripotency transcription factors remain associated with mitotic chromatin in ESCs and during iPSC reprogramming, demonstrating the importance of mitotic bookmarking in pluripotency.

Publication types

  • Comment

MeSH terms

  • Chromatin
  • Histone Code*
  • Mitosis
  • Pluripotent Stem Cells*
  • Transcription Factors


  • Chromatin
  • Transcription Factors