The Dynamic Identity of Intestinal Cancer Stem Cells

Cell Stem Cell. 2017 Jun 1;20(6):743-745. doi: 10.1016/j.stem.2017.05.018.


Elimination of self-renewing cancer stem cells (CSCs) is necessary to permanently eradicate malignant tissues. In a recent article in Nature, de Sousa e Melo et al. (2017) reveal that intestinal tumors can contain dynamic pools of functionally distinct CSC populations, which seem to interconvert depending on the host tissue microenvironment.

Publication types

  • Comment

MeSH terms

  • Humans
  • Neoplastic Stem Cells*