Stem Cells and Tissue Engineering: Regeneration of the Skin and Its Contents

Amy L Strong; Michael W Neumeister; Benjamin Levi

doi:10.1016/j.cps.2017.02.020

Stem Cells and Tissue Engineering: Regeneration of the Skin and Its Contents

Clin Plast Surg. 2017 Jul;44(3):635-650. doi: 10.1016/j.cps.2017.02.020. Epub 2017 Apr 22.

Authors

Amy L Strong¹, Michael W Neumeister², Benjamin Levi³

Affiliations

¹ Division of Plastic Surgery, Department of Surgery, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA.
² Department of Surgery, Institute for Plastic Surgery, Southern Illinois University School of Medicine, 747 North Rutledge Street, Springfield, IL 62702, USA.
³ Division of Plastic Surgery, Department of Surgery, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA; Burn Wound and Regenerative Medicine Laboratory, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address: blevi@med.umich.edu.

Abstract

In this review, the authors discuss the stages of skin wound healing, the role of stem cells in accelerating skin wound healing, and the mechanism by which these stem cells may reconstitute the skin in the context of tissue engineering.

Keywords: Adipose-derived stem cells; Bone marrow-derived mesenchymal stem cells; Epithelial stem cells; Hair follicle stem cells; Interfollicular epidermal stem cells; Mesenchymal stem cells; Umbilical cord mesenchymal stem cells.

Publication types

Review

MeSH terms

Animals
Burns / physiopathology
Burns / therapy*
Disease Models, Animal
Humans
Stem Cell Transplantation*
Tissue Engineering*
Wound Healing*

Grant support

K08 GM109105/GM/NIGMS NIH HHS/United States