Wake-sleep circuitry: an overview

Curr Opin Neurobiol. 2017 Jun;44:186-192. doi: 10.1016/j.conb.2017.03.021. Epub 2017 May 31.


Although earlier models of brain circuitry controlling wake-sleep focused on monaminergic and cholinergic arousal systems, recent evidence indicates that these play mainly a modulatory role, and that the backbone of the wake-sleep regulatory system depends upon fast neurotransmitters, such as glutmate and GABA. We review here recent advances in understanding the role these systems play in controlling sleep and wakefulness.

Publication types

  • Review

MeSH terms

  • Brain / physiology
  • Humans
  • Sleep / physiology*
  • Wakefulness / physiology*