Biologic Approaches to Problems of the Hand and Wrist

Orthop Clin North Am. 2017 Jul;48(3):343-349. doi: 10.1016/j.ocl.2017.03.010. Epub 2017 Apr 7.


Orthobiologics are not used as frequently in the hand and wrist as in other sites. The most frequently reported is the use of bone morphogenetic protein for the treatment of Kienböck disease. Animal studies have described improved tendon healing with the use of platelet-rich plasma (PRP), but no clinical studies have confirmed these results. PRP has been reported to produce improvements in the outcomes of distal radial fractures and osteoarthritis of the trapeziometacarpal in small numbers of patients. The use of orthobiologics in the hand and wrist are promising, but clinical trials are necessary to establish efficacy and safety.

Keywords: BMP; Hand; Kienböck disease; Orthobiologics; PRP; Wrist.

Publication types

  • Review

MeSH terms

  • Biological Therapy* / instrumentation
  • Biological Therapy* / methods
  • Bone Morphogenetic Proteins / pharmacology*
  • Fracture Healing / physiology*
  • Hand Injuries* / physiopathology
  • Hand Injuries* / therapy
  • Humans
  • Orthopedics / methods
  • Platelet-Rich Plasma*
  • Wrist Injuries* / physiopathology
  • Wrist Injuries* / therapy


  • Bone Morphogenetic Proteins