Choroidal Changes Associated With Subretinal Drusenoid Deposits in Age-related Macular Degeneration Using Swept-source Optical Coherence Tomography

Am J Ophthalmol. 2017 Aug;180:55-63. doi: 10.1016/j.ajo.2017.05.021. Epub 2017 Jun 1.

Abstract

Purpose: To compare choroidal vascular features of eyes with and without subretinal drusenoid deposits (SDD), using swept-source optical coherence tomography (SS OCT).

Design: Multicenter, cross-sectional study.

Methods: We prospectively recruited patients with intermediate age-related macular degeneration (AMD), without other vitreoretinal pathology. All participants underwent complete ophthalmic examination, color fundus photography (used for AMD staging), and spectral-domain OCT (to evaluate the presence of SDD). SS OCT was used to obtain automatic macular choroidal thickness (CT) maps, according to the Early Treatment Diabetic Retinopathy Study (ETDRS) sectors. For data analysis, we considered mean choroidal thickness as the arithmetic mean value of the 9 ETDRS sectors. SS OCT en face images of choroidal vasculature were also captured and converted to binary images. Choroidal vascular density (CVD) was calculated as a percent area occupied by choroidal vessels in a 6-mm-diameter submacular circular. Choroidal vessel volume was calculated by multiplying the average CVD by macular area and CT. Multilevel mixed linear models (to account for the inclusion of 2 eyes of same subject) were performed for analysis.

Results: We included 186 eyes (n = 118 subjects), 94 (50.5%) presenting SDD. Multiple regression analysis revealed that, controlling for age, eyes with SDD presented a statistically thinner mean CT (ß = -21.9, P = .006) and CT in all the individual ETDRS fields (ß ≤ -18.79, P ≤ .026). Mean choroidal vessel volume was also significantly reduced in eyes with SDD (ß = -0.003, P = .007). No significant associations were observed with mean CVD.

Conclusion: In subjects with intermediate AMD, choroidal thickness and vessel volume are reduced in the presence of subretinal drusenoid deposits.

Publication types

  • Comparative Study
  • Multicenter Study
  • Observational Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Choroid / blood supply
  • Choroid / pathology*
  • Choroidal Neovascularization / diagnostic imaging
  • Choroidal Neovascularization / etiology*
  • Cross-Sectional Studies
  • Female
  • Fluorescein Angiography
  • Humans
  • Male
  • Prospective Studies
  • Retinal Drusen / diagnostic imaging
  • Retinal Drusen / etiology*
  • Surveys and Questionnaires
  • Tomography, Optical Coherence
  • Wet Macular Degeneration / complications*
  • Wet Macular Degeneration / diagnostic imaging