Recent developments in the CCP-EM software suite

Acta Crystallogr D Struct Biol. 2017 Jun 1;73(Pt 6):469-477. doi: 10.1107/S2059798317007859. Epub 2017 May 31.


As part of its remit to provide computational support to the cryo-EM community, the Collaborative Computational Project for Electron cryo-Microscopy (CCP-EM) has produced a software framework which enables easy access to a range of programs and utilities. The resulting software suite incorporates contributions from different collaborators by encapsulating them in Python task wrappers, which are then made accessible via a user-friendly graphical user interface as well as a command-line interface suitable for scripting. The framework includes tools for project and data management. An overview of the design of the framework is given, together with a survey of the functionality at different levels. The current CCP-EM suite has particular strength in the building and refinement of atomic models into cryo-EM reconstructions, which is described in detail.

Keywords: CCP-EM; Collaborative Computational Project for Electron cryo-Microscopy; cryo-EM.

MeSH terms

  • Cryoelectron Microscopy / methods*
  • Software Design
  • Software*
  • User-Computer Interface