Contrast-Induced Nephropathy: Definitions, Epidemiology, and Implications

Peter A McCullough

doi:10.1016/j.iccl.2014.03.002

Contrast-Induced Nephropathy: Definitions, Epidemiology, and Implications

Interv Cardiol Clin. 2014 Jul;3(3):357-362. doi: 10.1016/j.iccl.2014.03.002. Epub 2014 Jun 28.

Author

Peter A McCullough¹

Affiliation

¹ Baylor University Medical Center, Baylor Heart and Vascular Institute, Baylor Jack and Jane Hamilton Heart and Vascular Hospital, 621 North Hall Street, #H030, Dallas, TX 75226, USA; The Heart Hospital, 1100 Allied Drive, Plano, TX 75093, USA. Electronic address: peteramccullough@gmail.com.

PMID: 28582220
DOI: 10.1016/j.iccl.2014.03.002

Abstract

Contrast-induced nephropathy, now termed contrast-induced acute kidney injury (CI-AKI), has been a long-recognized complication of administering intravascular iodinated contrast. This article reviews the newest literature on subclinical CI-AKI detected by novel biomarkers, and clinical CI-AKI recognized by an increase in serum creatinine and a reduction in urine output. Both components of CI-AKI are associated with adverse outcomes, including in-hospital complications, increased length of stay, need for renal replacement therapy, rehospitalization, permanent loss in renal filtration function, and death.

Keywords: Biomarkers; Chronic kidney disease; Contrast-induced acute kidney injury; Serum creatinine.

Publication types

Review