Histologic Chorioamnionitis and Bronchopulmonary Dysplasia in Preterm Infants: The Epidemiologic Study on Low Gestational Ages 2 Cohort

J Pediatr. 2017 Aug;187:98-104.e3. doi: 10.1016/j.jpeds.2017.05.019. Epub 2017 Jun 2.


Objective: To investigate the association between histologic chorioamnionitis (HCA) and bronchopulmonary dysplasia (BPD) in very preterm infants, both in a general population and for those born after spontaneous preterm labor and after preterm premature rupture of membranes (pPROM).

Study design: This study included 2513 live born singletons delivered at 24-31 weeks of gestation from a national prospective population-based cohort of preterm births; 1731 placenta reports were available. HCA was defined as neutrophil infiltrates in the amnion, chorion of the membranes, or chorionic plate, associated or not with funisitis. The main outcome measure was moderate or severe BPD. Analyses involved logistic regressions and multiple imputation for missing data.

Results: The incidence of HCA was 28.4% overall: 38% in cases of preterm labor, 64% in cases of pPROM, and less than 5% in cases of vascular disorders. Overall, the risk of BPD after adjustment for gestational age, sex, and antenatal steroids was reduced for infants with HCA (HCA alone: aOR 0.6 [95% CI 0.4-0.9]; associated with funisitis: aOR 0.5 [95% CI 0.3-0.8]). This finding was explained by the high rate of BPD and low rate of chorioamnionitis among children with fetal growth restriction. HCA was not associated with BPD in the preterm labor (13.4% vs 8.5%; aOR 0.9; 95% CI 0.5-1.8) or in the pPROM group (12.9% vs 12.1%; aOR 0.6; 95% CI 0.3-1.3).

Conclusion: In homogeneous groups of infants born after preterm labor or pPROM, HCA is not associated with BPD.

Keywords: bronchopulmonary dysplasia; chorioamnionitis; inflammation; premature birth; preterm labor; preterm premature rupture of the membranes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bronchopulmonary Dysplasia / complications
  • Bronchopulmonary Dysplasia / epidemiology*
  • Chorioamnionitis / epidemiology*
  • Epidemiologic Studies
  • Female
  • Fetal Membranes, Premature Rupture
  • Gestational Age
  • Humans
  • Incidence
  • Infant
  • Infant, Newborn
  • Infant, Premature
  • Logistic Models
  • Male
  • Pregnancy
  • Prospective Studies

Supplementary concepts

  • Preterm Premature Rupture of the Membranes