Visual and Motor Deficits in Grown-up Mice with Congenital Zika Virus Infection

EBioMedicine. 2017 Jun;20:193-201. doi: 10.1016/j.ebiom.2017.04.029. Epub 2017 Apr 24.

Abstract

Human infants with congenital Zika virus (ZIKV) infection exhibit a range of symptoms including microcephaly, intracranial calcifications, macular atrophy and arthrogryposis. More importantly, prognosis data have lagged far behind the recent outbreak of ZIKV in 2015. In this work, we allow congenitally ZIKV-infected mice to grow into puberty. These mice exhibited motor incoordination and visual dysfunctions, which can be accounted by anatomical defects in the retina and cerebellar cortex. In contrary, anxiety level of the ZIKV-infected mice is normal. The spectrum of anatomical and behavioral deficits is consistent across different mice. Our data provided evidence that may help predict the public health burden in terms of prognosis of ZIKV-related congenital brain malformations in an animal model. Our study provided behavioral evaluation for the prognosis of congenital ZIKV infection and provides a platform for screening and evaluation of drugs candidates and treatment aiming at improving regeneration of infected neurons to prevent sequelae caused by ZIKV infection of fetus.

Keywords: Congenital Zika syndrome; Intracranial calcifications; Prognosis evaluation; Visual and motor dysfunctions; ZIKV.

MeSH terms

  • Animals
  • Brain / diagnostic imaging
  • Brain / pathology
  • Brain / virology
  • Calcinosis
  • Cell Line
  • Disease Models, Animal
  • Female
  • Humans
  • Mice
  • Motor Disorders / diagnosis
  • Motor Disorders / etiology*
  • Motor Disorders / physiopathology
  • Paralysis / diagnosis
  • Paralysis / etiology
  • Paralysis / physiopathology
  • Pregnancy
  • Pregnancy Complications, Infectious*
  • Vision Disorders / diagnosis
  • Vision Disorders / etiology*
  • Vision Disorders / physiopathology
  • Zika Virus Infection / complications*
  • Zika Virus Infection / congenital*
  • Zika Virus Infection / diagnosis
  • Zika Virus Infection / virology
  • Zika Virus* / isolation & purification