Periodontal status and serum biomarker levels in HFE haemochromatosis patients. A case-series study

J Clin Periodontol. 2017 Sep;44(9):892-897. doi: 10.1111/jcpe.12760. Epub 2017 Aug 17.


Aim: To investigate the association between periodontal status and serum biomarkers in patients with HFE haemochromatosis.

Material and methods: This clinical case series included 84 HFE-C282Y homozygous patients. Periodontal evaluation was performed using clinical attachment level, probing depth, gingival bleeding index, visible plaque index and gingival index. Serum markers of iron metabolism were collected from medical records. The relationship between serum biomarkers of iron burden and the severity of periodontitis was investigated.

Results: The study population consisted of 47 men and 37 women, routinely treated in the Unit of Hepatology, University Hospital, Rennes. All patients presented with periodontitis (mild: n = 1, moderate: n = 37 and severe: n = 46). There was a positive association between transferrin saturation >45% and the severity of periodontitis (adjusted odds ratio = 5.49, p = .002).

Conclusion: Severe periodontitis is associated with the severity of iron burden in patients with HFE-related hereditary haemochromatosis. Dental examination should be included in the initial assessment of all these patients.

Keywords: haemochromatosis; iron burden; periodontitis; transferrin saturation.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Biomarkers / blood*
  • Female
  • Hemochromatosis / blood*
  • Hemochromatosis / genetics
  • Hemochromatosis Protein / genetics
  • Humans
  • Iron Overload / genetics
  • Male
  • Middle Aged
  • Periodontal Index
  • Periodontitis / blood*
  • Periodontitis / genetics


  • Biomarkers
  • HFE protein, human
  • Hemochromatosis Protein