A mutation in PTPN11 may drive leukemic transformation in a case of essential thrombocythemia

Leuk Lymphoma. 2018 Jan;59(1):245-248. doi: 10.1080/10428194.2017.1324162. Epub 2017 Jun 7.

Authors

Belinda B Guo¹, James Liang^{1

2}, Richard J N Allcock^{1

3}, Bob Mirzai^{1

3}, Bradley Augustson^{2

3}, Rebecca Howman^{2

3}, Kathryn A Fuller^{1

3}, Wendy N Erber^{1

3

4}

Affiliations

¹ a School of Biomedical Sciences, Faculty of Health and Medical Sciences , University of Western Australia , Crawley , WA , Australia.
² b Department of Haematology , Sir Charles Gairdner Hospital , Nedlands , WA , Australia.
³ c PathWest Laboratory Medicine , Nedlands , WA , Australia.
⁴ d School of Medicine, Faculty of Health and Medical Sciences , University of Western Australia , Crawley , WA , Australia.

PMID: 28587547
DOI: 10.1080/10428194.2017.1324162

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Acute Disease
Aged, 80 and over
Cell Transformation, Neoplastic / genetics*
Disease Progression
Humans
Leukemia, Myeloid / genetics*
Leukemia, Myeloid / pathology
Male
Mutation*
Protein Tyrosine Phosphatase, Non-Receptor Type 11 / genetics*
Thrombocythemia, Essential / genetics*
Thrombocythemia, Essential / pathology

Substances

PTPN11 protein, human
Protein Tyrosine Phosphatase, Non-Receptor Type 11