Hypoglycemia and decreased insulin requirement caused by malignant insulinoma in a type 1 diabetic patient: when the hoof beats are from a zebra, not a horse

Clin Case Rep. 2017 Apr 6;5(6):761-768. doi: 10.1002/ccr3.927. eCollection 2017 Jun.


Insulinomas are uncommon tumors, and in patients with diabetes mellitus they are extremely rare. We describe a patient with type 1 diabetes who developed malignant insulinoma. When hypoglycemic episodes persist in a patient with diabetes and treatment-induced and other causes of hypoglycemia have been ruled out, an insulin-producing tumor should be considered.

Keywords: Chromogranin; diabetes; hypoglycemia; insulin secretion; insulinoma.

Publication types

  • Case Reports