Prevalence of optimal valve morphology for MitraClip in patients with mitral regurgitation

Echocardiography. 2017 Aug;34(8):1122-1129. doi: 10.1111/echo.13592. Epub 2017 Jun 7.


Aims: To evaluate how often patients with moderate-to-severe or severe mitral regurgitation (MR) meet the anatomical criteria for MitraClip implant and to examine the role of transthoracic echocardiography (TTE) for this task.

Methods and results: From February to June 2015, all patients undergoing a TTE in nine Spanish hospitals were prospectively included. Patients with moderate-to-severe and severe mitral regurgitation were selected for analysis. Anatomical eligibility criteria for MitraClip were defined according to the EVEREST trial. A total of 39 855 consecutive TTE were reviewed, and 1403 patients with moderate-to-severe and severe MR were finally included. Primary MR was found in 779 patients (56%). Only in 74 patients (16%), all anatomical criteria for MitraClip could be assessed by TTE. Of these, 56% of patients had optimal valve morphology. Secondary MR was described in 361 patients (26%), and at least 249 of these (69%) had a high surgical risk. All five criteria for MitraClip were adequately assessed by TTE in 299 patients (83%). Of them, 118 patients (39%) had optimal valve morphology.

Conclusions: A considerable proportion of patients have optimal mitral valve morphology for MitraClip. Moreover, TTE was particularly useful in determining whether or not the anatomical criteria for MitraClip implant were met in the majority of patients with secondary MR but in only a minority of those with primary MR.

Keywords: echocardiography; mitral regurgitation; percutaneous intervention.

Publication types

  • Clinical Trial
  • Multicenter Study

MeSH terms

  • Aged
  • Echocardiography, Transesophageal / methods*
  • Female
  • Follow-Up Studies
  • Heart Valve Prosthesis*
  • Humans
  • Male
  • Mitral Valve / diagnostic imaging*
  • Mitral Valve / surgery
  • Mitral Valve Insufficiency / diagnosis*
  • Mitral Valve Insufficiency / epidemiology
  • Mitral Valve Insufficiency / surgery
  • Prevalence
  • Prospective Studies
  • Prosthesis Design
  • Severity of Illness Index
  • Spain / epidemiology