Retina. 2017 Nov;37(11):2095-2101. doi: 10.1097/IAE.0000000000001456.


Purpose: To describe the optical coherence tomography angiography (OCTA) characteristics of active myopic choroidal neovascularization (CNV) and to compare its sensitivity versus fluorescein angiography and spectral-domain optical coherence tomography.

Methods: Consecutive highly myopic patients complicated with active myopic CNV were prospectively included. The OCTA features were analyzed and correlated with the findings of conventional imaging (spectral-domain optical coherence tomography and fluorescein angiography).

Results: Twenty eyes of 19 patients (mean age: 59.6 ± 12.1 years, mean spherical equivalent: -13.5 ± 3.6 diopters) presenting with both treatment-naive CNV and recurrent CNV were included in the analysis. The OCTA showed a 90% sensitivity for myopic CNV detection in 18 of 20 eyes, revealing a high-flow neovascular network accurately visible using a 30-μm manual segmentation underneath Bruch membrane. Mean selected area of myopic CNV on OCTA images was 0.34 ± 0.45 mm, whereas the mean vessel area was 0.22 ± 0.27 mm. Two neovascular phenotypes prevailed in our series: disorganized vascular loops and organized interlacing patterns.

Conclusion: The OCTA seems to be a valuable tool in detecting myopic CNV with a high sensitivity. However, its specificity needs to be investigated in further studies.

MeSH terms

  • Adult
  • Aged
  • Bruch Membrane / pathology
  • Choroid / blood supply*
  • Choroidal Neovascularization / diagnosis*
  • Choroidal Neovascularization / etiology
  • Disease Progression
  • Female
  • Fluorescein Angiography / methods*
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Myopia, Degenerative / complications*
  • Myopia, Degenerative / diagnosis
  • Myopia, Degenerative / physiopathology
  • Refraction, Ocular*
  • Reproducibility of Results
  • Retrospective Studies
  • Tomography, Optical Coherence / methods*
  • Visual Acuity