Treatment with beta-adrenoceptor blockers reduces plasma melatonin concentration

Br J Clin Pharmacol. 1985 Feb;19(2):258-60. doi: 10.1111/j.1365-2125.1985.tb02640.x.


In treated hypertensive patients plasma melatonin levels were lower in subjects receiving beta-adrenoceptor blockers than those treated with diuretics. Melatonin concentrations in middle-aged and young control subjects were similar to each other and to those of the diuretic-treated patients. The results suggest that treatment with beta-adrenoceptor blockers causes a persistent reduction in plasma melatonin but it is unclear if this finding has clinical implications.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic beta-Antagonists / therapeutic use*
  • Adult
  • Age Factors
  • Aged
  • Diuretics / therapeutic use
  • Female
  • Humans
  • Hypertension / drug therapy*
  • Male
  • Melatonin / blood*
  • Middle Aged


  • Adrenergic beta-Antagonists
  • Diuretics
  • Melatonin