Abstract
Chronic haloperidol treatment markedly increases dynorphin-related peptide contents in caudate-putamen, globus pallidus and substantia nigra. Leu-enkephalin levels follow dynorphin-related peptide concentrations in these areas while Met-enkephalin-related peptide contents are unchanged in the substantia nigra following a similar treatment. An acute haloperidol injection had no effect on any opioid peptide levels in the basal ganglia. This suggests that Leu-enkephalin is likely to be derived from prodynorphin in the rat striatonigral pathway. Moreover, the Leu-enkephalin/dynorphin projection appears to be under striatal dopaminergic control.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Caudate Nucleus / analysis
-
Corpus Striatum / analysis*
-
Corpus Striatum / physiology
-
Dopamine / physiology*
-
Dynorphins / analogs & derivatives*
-
Dynorphins / analysis
-
Dynorphins / physiology
-
Endorphins / analysis*
-
Enkephalin, Leucine / analysis*
-
Enkephalin, Methionine / analogs & derivatives*
-
Enkephalin, Methionine / analysis
-
Globus Pallidus / analysis
-
Haloperidol / pharmacology*
-
Male
-
Putamen / analysis
-
Rats
-
Rats, Inbred Strains
-
Substantia Nigra / analysis*
Substances
-
Endorphins
-
Enkephalin, Methionine
-
Enkephalin, Leucine
-
Dynorphins
-
enkephalin-Met, Arg(6)-Gly(7)-Leu(8)-
-
rimorphin
-
Haloperidol
-
Dopamine