Possible interactions between dynorphin and dopaminergic systems in rat basal ganglia and substantia nigra

Brain Res. 1985 Apr 8;331(2):358-62. doi: 10.1016/0006-8993(85)91563-x.

Abstract

Chronic haloperidol treatment markedly increases dynorphin-related peptide contents in caudate-putamen, globus pallidus and substantia nigra. Leu-enkephalin levels follow dynorphin-related peptide concentrations in these areas while Met-enkephalin-related peptide contents are unchanged in the substantia nigra following a similar treatment. An acute haloperidol injection had no effect on any opioid peptide levels in the basal ganglia. This suggests that Leu-enkephalin is likely to be derived from prodynorphin in the rat striatonigral pathway. Moreover, the Leu-enkephalin/dynorphin projection appears to be under striatal dopaminergic control.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Caudate Nucleus / analysis
  • Corpus Striatum / analysis*
  • Corpus Striatum / physiology
  • Dopamine / physiology*
  • Dynorphins / analogs & derivatives*
  • Dynorphins / analysis
  • Dynorphins / physiology
  • Endorphins / analysis*
  • Enkephalin, Leucine / analysis*
  • Enkephalin, Methionine / analogs & derivatives*
  • Enkephalin, Methionine / analysis
  • Globus Pallidus / analysis
  • Haloperidol / pharmacology*
  • Male
  • Putamen / analysis
  • Rats
  • Rats, Inbred Strains
  • Substantia Nigra / analysis*

Substances

  • Endorphins
  • Enkephalin, Methionine
  • Enkephalin, Leucine
  • Dynorphins
  • enkephalin-Met, Arg(6)-Gly(7)-Leu(8)-
  • rimorphin
  • Haloperidol
  • Dopamine