Multiple Motifs Compete for EB-Dependent Microtubule Plus End Binding

Structure. 2017 Jun 6;25(6):821-822. doi: 10.1016/j.str.2017.05.017.


Microtubule (MT) dynamics are regulated by a plethora of microtubule-associated proteins (MAPs). An important MT regulator is the end binding protein EB, which serves as a scaffold to recruit other MAPs to MT plus ends. In this issue of Structure, Kumar et al. (2017) describe LxxPTPh, a new linear sequence motif that can bind EBs. The finding opens up the possibility of discovering new MT regulators.

Publication types

  • Comment

MeSH terms

  • Carrier Proteins
  • Microtubule-Associated Proteins*
  • Microtubules*
  • Protein Binding


  • Carrier Proteins
  • Microtubule-Associated Proteins